BiologicalActivity
PotentandselectiveTpl2(Cot;MAP3K8)inhibitor(IC50=50nM).SelectiveforTpl2overMEK,p38,Src,MK2,PKCandEGFR.InhibitsLPS-inducedTNF-αsecretionfrommonocytesandattenuatesacutemyeloidleukemia(AML)cellproliferationinvitro.AlsoreducescytolyticactivityofhumanCD8+cytotoxicTlymphocytes.Cellpermeable.
CompoundLibraries
TC-S7006isalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxII.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 404.83 |
| Formula | C21H14ClFN6 |
| Storage | Storeat-20°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 871307-18-5 |
| PubChemID | 9549300 |
| InChIKey | NMEUKWOOQOHUNA-UHFFFAOYSA-N |
| Smiles | FC(C(Cl)=C4)=CC=C4NC1=C2C(C=NC(NCC3=CN=CC=C3)=C2)=NC=C1C#N |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 40.48 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight404.83.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.47mL | 12.35mL | 24.7mL |
| 5mM | 0.49mL | 2.47mL | 4.94mL |
| 10mM | 0.25mL | 1.24mL | 2.47mL |
| 50mM | 0.05mL | 0.25mL | 0.49mL |
MolarityCalculator
ReconstitutionCalculator
DilutionCalculator
ProductDatasheets
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