Biological Activity
Potent and selective S1P1 agonist (EC50 values are 0.042 and 3.47 μM for human S1P1 and S1P3 respectively). Attenuates immune response to antigen challenge and reduces circulating blood lymphocyte counts in a rodent model of delayed-type hypersensitivity. Orally bioavailable.
Compound Libraries
TC-SP 14 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 450.5 |
| Formula | C25H20F2N2O2S |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 1257093-40-5 |
| PubChem ID | 51346934 |
| InChI Key | GVXGVDIXINMAAL-UHFFFAOYSA-N |
| Smiles | FC(C=C(CN4CC(C(O)=O)C4)C=C3)=C3C2=NC1=CC(CC5=CC=CC=C5F)=CC=C1S2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 22.52 | 50mM with gentle warming |
Preparing Stock Solutions
The following data is based on the product molecular weight 450.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.22 mL | 11.1 mL | 22.2 mL |
| 5 mM | 0.44 mL | 2.22 mL | 4.44 mL |
| 10 mM | 0.22 mL | 1.11 mL | 2.22 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.44 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Lanman et al (2011) Discovery of a potent, S1P3-sparing benzothiazole agonist of sphingosine-1-phosphate receptor 1 (S1P1). ACS Med.Chem.Lett. 2 102 PMID:
Keywords: TC-SP 14, supplier, TCSP14, Potent, sphingosine, 1, phosphate, 1, receptor, S1P1, agonist, delayed, type, hypersensitivity, immune, response, orally, bioavailable, Sphingosine-1-phosphate, Receptors, Sphingosine-1-phosphate, Receptors, Tocris Bioscience
