Biological Activity
Potent equilibrative nucleoside transporter 4 (ENT4) inhibitor (IC50 = 74.4 nM). Exhibits 20-fold and 80-fold selectivity for ENT4 over ENT2 and ENT1, respectively.
Technical Data
| M. Wt | 504.71 |
| Formula | C26H48N8O2 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 949467-71-4 |
| PubChem ID | 16757265 |
| InChI Key | KIZLZYHFIWWKIL-UHFFFAOYSA-N |
| Smiles | CC(C)CN(CC(C)C)C2=NC(NCCO)=NC1=C(N(CC(C)C)CC(C)C)N=C(NCCO)N=C12 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 10.09 | 20 | |
| ethanol | 10.09 | 20 |
Preparing Stock Solutions
The following data is based on the product molecular weight 504.71. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.98 mL | 9.91 mL | 19.81 mL |
| 5 mM | 0.4 mL | 1.98 mL | 3.96 mL |
| 10 mM | 0.2 mL | 0.99 mL | 1.98 mL |
| 50 mM | 0.04 mL | 0.2 mL | 0.4 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Wang et al (2013) Dipyridamole analogs as pharmacological inhibitors of equilibrative nucleoside transporters. Identification of novel potent and selective inhibitors of the adenosine transporter function of human equilibrative nucleoside transporter 4 (hENT4). Biochem.Pharmacol. 86 1531 PMID: 24021350
Keywords: TC-T 6000, supplier, potent, selective, ENT4, inhibitors, inhibits, equilibrative, nucleoside, transporter, 4, Nucleoside, Transporters, Nucleoside, Transporters, Tocris Bioscience
