Biological Activity
NMDA receptor antagonist, selective for NR1/NR2A (pIC50 = 5.4) over NR1/NR2B.
Technical Data
| M. Wt | 376.54 |
| Formula | C18H24N4OS2 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 556803-08-8 |
| PubChem ID | 2608149 |
| InChI Key | XBAZPYFIYYCZBO-UHFFFAOYSA-N |
| Smiles | O=C(NCC2CCCCC2)CSC1=NN=C(NCC3=CC=CC=C3)S1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 28.24 | 75 | |
| ethanol | 3.77 | 10 |
Preparing Stock Solutions
The following data is based on the product molecular weight 376.54. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.66 mL | 13.28 mL | 26.56 mL |
| 5 mM | 0.53 mL | 2.66 mL | 5.31 mL |
| 10 mM | 0.27 mL | 1.33 mL | 2.66 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.53 mL |
Molarity Calculator
Reconstitution Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Bettini et al (2010) Identification and characterization of novel NMDA receptor antagonists selective for NR2A- over NR2B-containing receptors. J.Pharmacol.Exp.Ther. 335 644 PMID: 20810618
McKay et al (2012) Direct pharmacological monitoring of the developmental switch in NMDAR subunit composition using TCN 213, a GluN2A-selective, glycine-dependent antagonist. Br.J.Pharmacol. 166 924 PMID: 22022974
Keywords: TCN 213, supplier, TCN213, selective, NMDA, receptor, antagonist, NR1/NR2A, NR2A-containing, NR2B, NMDA, Receptors, NMDA, Receptors, Tocris Bioscience
