Biological Activity
Positive allosteric modulator of mGlu4 receptors (EC50 = 1.0 μM for human and rat mGlu4 receptors). Orally available and brain penetrant.
Compound Libraries
TCN 238 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 197.24 |
| Formula | C12H11N3 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 125404-04-8 |
| PubChem ID | 46911068 |
| InChI Key | LNUXNUNUGIHCPA-VOTSOKGWSA-N |
| Smiles | NC1=NC(/C=C/C2=CC=CC=C2)=CC=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 19.72 | 100 | |
| ethanol | 1.97 | 10 |
Preparing Stock Solutions
The following data is based on the product molecular weight 197.24. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5.07 mL | 25.35 mL | 50.7 mL |
| 5 mM | 1.01 mL | 5.07 mL | 10.14 mL |
| 10 mM | 0.51 mL | 2.53 mL | 5.07 mL |
| 50 mM | 0.1 mL | 0.51 mL | 1.01 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
East et al (2010) An orally bioavailable positive allosteric modulator of the mGlu4 receptor with efficacy in an animal model of motor dysfunction. Bioorg.Med.Chem.Lett. 20 4901 PMID: 20638279
Keywords: TCN 238, supplier, TCN238, metabotropic, glutamate, mglu4, positive, allosteric, modulators, pams, Glutamate, (Metabotropic), Group, III, Receptors, Glutamate, (Metabotropic), Group, III, Receptors, Tocris Bioscience
