Biological Activity
GABAA benzodiazepine receptor (BZR) ligand. Acts as an agonist at α2 and antagonist at α1 benzodiazepine receptors (Ki values are 118 and 245 nM respectively). Anxiolytic agent lacking sedative activity.
Technical Data
| M. Wt | 296.3 |
| Formula | C17H13FN2O2 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 185391-33-7 |
| PubChem ID | 2986030 |
| InChI Key | VWCCHJFFYCGXFL-UHFFFAOYSA-N |
| Smiles | O=C(C(NCC3=CC=C(F)C=C3)=O)C2=CNC1=CC=CC=C12 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 29.63 | 100 | |
| ethanol | 5.93 | 20 |
Preparing Stock Solutions
The following data is based on the product molecular weight 296.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.37 mL | 16.87 mL | 33.75 mL |
| 5 mM | 0.67 mL | 3.37 mL | 6.75 mL |
| 10 mM | 0.34 mL | 1.69 mL | 3.37 mL |
| 50 mM | 0.07 mL | 0.34 mL | 0.67 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Taliani et al (2009) Identification of anxiolytic/nonsedative agents among indol-3-ylglyoxylamides acting as functionally selective agonists at the γ-aminobutyric acid-A (GABAA) α2 benzodiazepine receptor. J.Med.Chem 52 3723 PMID: 19469479
Keywords: TCS 1105, supplier, TCS1105, alpha2, agonist, alpha1, antagonist, GABA, a1, a2, α2, α1, GABAA, benzodiazepine, receptor, BZR, GABAA, Receptors, GABAA, Receptors, Tocris Bioscience
