Biological Activity
Fragment 1-13 of human and mouse GSK-3β sequence. Potentially useful as a competitive inhibitor of GSK-3β (Ser9) phosphorylation. Control peptide TCS 184 available (Cat. No. 2320).
Technical Data
| M. Wt | 1425.58 |
| Formula | C58H96N20O20S |
| Sequence |
MSGRPRTTSFAES (Modifications: Ser-13 = C-terminal amide) |
| Storage | Desiccate at -20°C |
| PubChem ID | 90488752 |
| InChI Key | CPHAYBWPVDHKAJ-BOGMMOMNSA-N |
| Smiles | [H]N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 1 mg/ml in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 1425.58. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.7 mL | 3.51 mL | 7.01 mL |
| 5 mM | 0.14 mL | 0.7 mL | 1.4 mL |
| 10 mM | 0.07 mL | 0.35 mL | 0.7 mL |
| 50 mM | 0.01 mL | 0.07 mL | 0.14 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Peineau et al (2007) GSK3β mediates a novel interaction between LTP and LTD in the hippocampus. Neuron 53 703 PMID: 17329210
Keywords: TCS 183, supplier, Fragment, 1-13, GSK-3β, GSK-3beta, sequence, Glycogen, Synthase, Kinases, 3, Carbohydrate, Metabolism, TCS183, Glycogen, Synthase, Kinase, 3, Glycogen, Synthase, Kinase, Glycogen, Synthase, Kinase, 3, Tocris Bioscience
