Tocris/TCS 21311/4221/10/10 mg-免疫在线蚂蚁淘旗下平台

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商品详细Tocris/TCS 21311/4221/10/10 mg

Tocris/TCS 21311/4221/10/10 mg

商品编号： 4221/10

品牌： Tocris Bioscience

市场价： ¥4700.00

美元价： 2820.00

产地：美国(厂家直采)

公司：

产品分类：其它酶

公司分类： Other_enzymes

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Description:PotentJAK3inhibitor.AlsoinhibitsGSK-3βandPKC

AlternativeNames:NIBR3049

ChemicalName:3-[5-[4-(2-Hydroxy-2-methyl-1-oxopropyl)-1-piperazinyl]-2-(trifluoromethyl)phenyl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentJAK3inhibitor(IC₅₀=8nM).SelectiveforJAK3overJAK1,JAK2andTYK2(IC₅₀valuesare1017,2550and8055nMrespectively).AlsoinhibitsGSK-3β,PKCαandPKCθ(IC₅₀valuesare3,13and68nMrespectively).

CompoundLibraries

TCS21311isalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxII.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	526.51
Formula	C₂₇H₂₅F₃N₄O₄
Storage	DesiccateatRT
Purity	≥98%(HPLC)
CASNumber	1260181-14-3
PubChemID	50925411
InChIKey	CLGRAWDGLMENOD-UHFFFAOYSA-N
Smiles	O=C(N1)C(C3=CNC4=C3C=CC=C4)=C(C2=C(C(F)(F)F)C=CC(N5CCN(C(C(O)(C)C)=O)CC5)=C2)C1=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	DMSO	52.65	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight526.51.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	1.9mL	9.5mL	18.99mL
5mM	0.38mL	1.9mL	3.8mL
10mM	0.19mL	0.95mL	1.9mL
50mM	0.04mL	0.19mL	0.38mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

SafetyDatasheet

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BiologicalActivity

CompoundLibraries

TechnicalData

SolubilityData

PreparingStockSolutions

MolarityCalculator

ReconstitutionCalculator

DilutionCalculator

ProductDatasheets