BiologicalActivity
PotentandselectiveSUV420H1/H2inhibitor(IC50valuesare25and144nMrespectively).Exhibits100-foldselectivityoverotherhistonemethyltransferasesandnon-epigenetictargets.Inhibitsthedi-andtri-methylationofH4K20meinmultiplecelllines(IC50<1μM).
LicensingInformation
ThisprobeissuppliedinconjunctionwiththeStructuralGenomicsConsortium.Forfurthercharacterizationdetails,pleasevisittheA-196probesummaryontheSGCwebsite.
Chemicalprobes.orgisaportalthatoffersindependentguidanceontheselectionand/orapplicationofsmallmoleculesforresearch.TheuseofA196isreviewedontheChemicalProbeswebsite.
TechnicalData
| M.Wt | 359.25 |
| Formula | C18H16Cl2N4 |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 1982372-88-2 |
| Smiles | ClC1=CC2=C(C(C3=CC=NC=C3)=NN=C2NC4CCCC4)C=C1Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 7.18 | 20 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight359.25.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.78mL | 13.92mL | 27.84mL |
| 5mM | 0.56mL | 2.78mL | 5.57mL |
| 10mM | 0.28mL | 1.39mL | 2.78mL |
| 50mM | 0.06mL | 0.28mL | 0.56mL |
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