Biological Activity
Selective inhibitor of JNK2 and JNK3 (pIC50 values are 6.7, 6.5, <5.0 and <4.8 for JNK3, JNK2, JNK1 and p38α respectively). Displays no significant activity at a range of other protein kinases including EGFR, ErbB2, cdk2, PLK-1 and Src (pIC50 < 5.0).
Technical Data
| M. Wt | 332.42 |
| Formula | C20H16N2OS |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 312917-14-9 |
| PubChem ID | 766949 |
| InChI Key | WQGDQGAFSDMBLA-UHFFFAOYSA-N |
| Smiles | O=C(C3=CC=CC4=C3C=CC=C4)NC2=C(C#N)C1=C(S2)CCCC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 33.24 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 332.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.01 mL | 15.04 mL | 30.08 mL |
| 5 mM | 0.6 mL | 3.01 mL | 6.02 mL |
| 10 mM | 0.3 mL | 1.5 mL | 3.01 mL |
| 50 mM | 0.06 mL | 0.3 mL | 0.6 mL |
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References
References are publications that support the products' biological activity.
Angell et al (2007) N-(3-cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)amides as potent, selective, inhibitors of JNK2 and JNK3. Bioorg.Med.Chem.Letts. 17 1296 PMID:
Keywords: TCS JNK 5a, supplier, Selective, inhibitors, inhibits, JNK2, JNK3, Mitogen-Activated, Protein, Kinases, MAPK, c-Jun, N-Terminal, SAPKs, Stress-Activated, TCSJNK5a, JNK/c-jun, JNK/c-jun, Tocris Bioscience
