Biological Activity
Potent hematopoietic prostaglandin D synthase (H-PGDS) inhibitor (IC50 = 83 nM). Inhibits PGD2 production and late phase nasal blockage in an animal model of allergic rhinitis. Exhibits negligible effects on COX-1, COX-2, 5-LOX, LTC4 synthase, TXA2 synthase and microsomal prostaglandin E2 synthase.
Compound Libraries
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Technical Data
| M. Wt | 487.55 |
| Formula | C27H29N5O4 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 927878-49-7 |
| PubChem ID | 16040067 |
| InChI Key | NLSSUSRERAMBTA-UHFFFAOYSA-N |
| Smiles | O=C(C2CCN(C3=CC=C(NC(C4=CN=C(OC5=CC=CC=C5)N=C4)=O)C=C3)CC2)N1CCOCC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 48.76 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 487.55. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.05 mL | 10.26 mL | 20.51 mL |
| 5 mM | 0.41 mL | 2.05 mL | 4.1 mL |
| 10 mM | 0.21 mL | 1.03 mL | 2.05 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.41 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Nabe et al (2011) Inhibition of hematopoietic prostaglandin D synthase improves allergic nasal blockage in guinea pigs. Prostaglandins Other Lipid Mediat. 95 27 PMID: 21601002
Keywords: TFC 007, supplier, TFC007, hematopoietic, prostaglandin, D, synthase, HPGDS, inhibitors, inhibits, antiallergic, anti-inflammatory, Other, Synthases/Synthetases, Other, Synthases/Synthetases, Tocris Bioscience
