Biological Activity
Peptide derived from the protease-activated receptor-1 (PAR1) that acts as a PAR1 selective agonist (EC50 = 1.9 μM). Stimulates PAR1-mediated plasma extravasation in vivo. Control Peptide RLLFT-NH2 (Cat. No. 3393) also available.
Technical Data
| M. Wt | 647.82 |
| Formula | C31H53N9O6 |
| Sequence |
TFLLR (Modifications: Arg-5 = C-terminal amide) |
| Storage | Desiccate at -20°C |
| CAS Number | 197794-83-5 |
| PubChem ID | 10146183 |
| InChI Key | ANAMCEKSRDPIPX-GFGQVAFXSA-N |
| Smiles | [H]N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 1 mg/ml in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 647.82. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.54 mL | 7.72 mL | 15.44 mL |
| 5 mM | 0.31 mL | 1.54 mL | 3.09 mL |
| 10 mM | 0.15 mL | 0.77 mL | 1.54 mL |
| 50 mM | 0.03 mL | 0.15 mL | 0.31 mL |
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References
References are publications that support the products' biological activity.
de Garavilla et al (2001) Agonists of proteinase-activated receptor 1 induce plasma extravasation by a neurogenic mechanism. Br.J.Pharmacol. 133 975 PMID: 11487506
Hollenberg et al (1997) Proteinase-activated receptors: structural requirements for activity, receptor cross-reactivity, and receptor selectivity of receptor-activating peptides. Can.J.Physiol.Pharmacol. 75 832 PMID: 9315351
Kawabata et al (2000) Characterization of the protease-activated receptor-1-mediated contraction and relaxation in the rat duodenal smooth muscle. Life Sci. 67 2521 PMID: 11065174
Keywords: TFLLR-NH2, supplier, PAR1-activating, peptide, PAR, Receptors, Protease-Activated, proteinase-activated, Protease-Activated, Receptors, Protease-Activated, Receptors, Tocris Bioscience
