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商品详细Tocris/TG 003/4336/50/50 mg

Tocris/TG 003/4336/50/50 mg

商品编号： 4336/50

品牌： Tocris Bioscience

市场价： ¥15300.00

美元价： 9180.00

产地：美国(厂家直采)

公司：

产品分类：其它酶

公司分类： Other_enzymes

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Description:PotentinhibitorofClk-familykinases;alsoinhibitsDYRK1A/B

ChemicalName:(1Z)-1-(3-Ethyl-5-methoxy-2(3H)-benzothiazolylidene)-2-propanone

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Potent,ATP-competitiveinhibitorofClk-familykinases(IC₅₀valuesare15,20and200nMformClk4,1and2respectivelyand>10μMformClk3).AlsoinhibitsDYRK1A/B(IC₅₀valuesare24and34nMrespectively).Suppressesserine/arginine-richproteinphosphorylation;affectstheregulationofalternativesplicingbyphosphorylationofSRproteinbothinvitroandinvivo.

TechnicalData

M.Wt	249.33
Formula	C₁₃H₁₅NO₂S
Storage	Storeat+4°C
Purity	≥98%(HPLC)
CASNumber	719277-26-6
PubChemID	647991
InChIKey	BGVLELSCIHASRV-UHFFFAOYSA-N
Smiles	O=C(C)/C=C1SC2=CC=C(OC)C=C2N1CC

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	24.93	100
	ethanol	18.7	75

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight249.33.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	4.01mL	20.05mL	40.11mL
5mM	0.8mL	4.01mL	8.02mL
10mM	0.4mL	2.01mL	4.01mL
50mM	0.08mL	0.4mL	0.8mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

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TechnicalData

SolubilityData

PreparingStockSolutions

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