Biological Activity
High affinity and selective EP2 receptor antagonist (KB values are 2.4 and 34.5 nM for EP2 and DP1 receptors respectively). Exhibits >500-fold selectivity for EP2 over other prostanoid receptors. Inhibits butaprost-induced proinflammatory cytokine production, cell proliferation and invasion of PC-3 cells in vitro.
Technical Data
| M. Wt | 394.46 |
| Formula | C23H26N2O4 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1164462-05-8 |
| PubChem ID | 5886965 |
| InChI Key | YBHUXHFZLMFETJ-MDZDMXLPSA-N |
| Smiles | CC2=CC1=CC=CC=C1N2CCNC(/C=C/C3=CC(OC)=C(OC)C(OC)=C3)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.45 | 100 | |
| ethanol | 7.89 | 20 |
Preparing Stock Solutions
The following data is based on the product molecular weight 394.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.54 mL | 12.68 mL | 25.35 mL |
| 5 mM | 0.51 mL | 2.54 mL | 5.07 mL |
| 10 mM | 0.25 mL | 1.27 mL | 2.54 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.51 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Jiang and Dingledine (2013) Role of prostaglandin receptor EP2 in the regulations of cancer cell proliferation, invasion, and inflammation. J.Pharmacol.Exp.Ther. 344 360 PMID: 23192657
Quan et al (2013) EP2 receptor signaling pathways regulate classical activation of microglia. J.Biol.Chem. 288 9293 PMID: 23404506
Keywords: TG 4-155, supplier, TG4-155, high, affinity, selective, EP2, prostanoid, receptors, antagonists, Prostanoid, Receptors, Prostanoid, Receptors, Tocris Bioscience
