Biological Activity
Systemically active GABAA receptor agonist and GABAA-ρ receptor antagonist. Displays antinociceptive, anticonvulsant and sedative effects. Hypnotic agent that enhances delta activity within non-REM sleep in rats.
Compound Libraries
THIP hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 176.6 |
| Formula | C6H8N2O2.HCl |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 85118-33-8 |
| PubChem ID | 5702253 |
| InChI Key | ZDZDSZQYRBZPNN-UHFFFAOYSA-N |
| Smiles | Cl.OC1=NOC2=C1CCNC2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 17.66 | 100 | |
| water | 17.66 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 176.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5.66 mL | 28.31 mL | 56.63 mL |
| 5 mM | 1.13 mL | 5.66 mL | 11.33 mL |
| 10 mM | 0.57 mL | 2.83 mL | 5.66 mL |
| 50 mM | 0.11 mL | 0.57 mL | 1.13 mL |
Molarity Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Huckle (2004) Gaboxadol. Lundbeck/Merck Curr.Opin.Investig.Drugs 5 766 PMID: 15298075
Johnston (1996) GABAC receptors: relatively simple transmitter-gated ion channels? TiPS 17 319 PMID: 8885697
Krogsgaard-Larson (1983) 4,5,6,7-Tetrahydroisothiazolo[5,4-c]pyridin-3-ol and related analogues of THIP. Synthesis and biological activity. J.Med.Chem. 26 895 PMID: 6304315
Krogsgaard-Larson (1984) Chemistry and pharmacology of the GABA antagonists THIP (Gaboxadol) and isoguvacine. Drugs Future. 9 597 PMID:
Keywords: THIP hydrochloride, supplier, GABAC, antagonists, GABAA, agonists, Receptors, Gaboxadol, GABAA, Receptors, GABAA-rho, Receptors, GABAA, Receptors, Tocris Bioscience
