Biological Activity
Reversible inositol hexakisphosphate kinase (IP6K) inhibitor (IC50 = 0.47 μM for inhibition of InsP7 formation). Also inhibits inositol 1,4,5-trisphosphate 3-kinase (IP3K) (IC50 = 10.2 μM). Binds to the ATP binding site of IP3K (Ki = 4.3 μM).
Technical Data
| M. Wt | 443.38 |
| Formula | C20H16F3N7O2 |
| Storage | Store at +4°C |
| Purity | ≥97% (HPLC) |
| CAS Number | 519178-28-0 |
| PubChem ID | 16760513 |
| InChI Key | DDSBPUYZPWNNGH-UHFFFAOYSA-N |
| Smiles | O=[N+](C(C=C4)=CC=C4CNC1=C2C(NC=N2)=NC(NCC3=CC=CC(C(F)(F)F)=C3)=N1)[O-] |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 44.34 | 100 | |
| ethanol | 11.08 | 25 |
Preparing Stock Solutions
The following data is based on the product molecular weight 443.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.26 mL | 11.28 mL | 22.55 mL |
| 5 mM | 0.45 mL | 2.26 mL | 4.51 mL |
| 10 mM | 0.23 mL | 1.13 mL | 2.26 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.45 mL |
Molarity Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Padmanabhan et al (2009) Characterization of a selective inhibitor of inositol hexakisphosphate kinases. Use in defining biological roles and metabolic relationships of inositol pyrophosphates. J.Biol.Chem. 284 10571 PMID: 19208622
Chang et al (2002) Purine-based inhibitors of inositol-1,4,5-trisphosphate-3-kinase. Chembiochem 3 897 PMID: 12210991
Keywords: TNP, supplier, TNP, inhibitors, inhibits, inositol, 1,4,5-triphosphate, 3-kinase, IP3K, hexakisphosphate, kinases, IP6K, lipids, Other, Kinases, Inositol, Lipids, Other, Kinases, Tocris Bioscience
