Biological Activity
Extremely potent analog of retinoic acid, selective for the retinoic acid receptor (RAR) subtype. Enhances reprogramming efficiency in chemically induced pluripotent stem cells (CiPSCs).
Technical Data
| M. Wt | 348.48 |
| Formula | C24H28O2 |
| Storage | Desiccate at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 71441-28-6 |
| PubChem ID | 5289501 |
| InChI Key | FOIVPCKZDPCJJY-JQIJEIRASA-N |
| Smiles | CC(=C/C1=CC=C(C=C1)C(O)=O)C1=CC=C2C(=C1)C(C)(C)CCC2(C)C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 3.48 | 10 | |
| ethanol | 1.74 | 5mM with gentle warming |
Preparing Stock Solutions
The following data is based on the product molecular weight 348.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.87 mL | 14.35 mL | 28.7 mL |
| 5 mM | 0.57 mL | 2.87 mL | 5.74 mL |
| 10 mM | 0.29 mL | 1.43 mL | 2.87 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.57 mL |
Molarity Calculator
Reconstitution Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Minucci et al (1996) Retinoid X receptor-selective ligands produce malformations in Xenopus embryos. Proc.Natl.Acad.Sci.U.S.A. 93 1803 PMID: 8700839
Loeliger et al (1980) Arotinoids, a new class of highly active retinoids. Eur.J.Med.Chem.-Chim.Ther. 15 9 PMID:
Hou et al (2013) Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds. Science 341 651 PMID: 23868920
Keywords: TTNPB, supplier, Retinoic, acid, analogs, agonists, RAR, Receptors, Ro, 13-7410, Ro, 13-7410, Retinoic, Acid, Receptors, Reprogramming, Retinoic, Acid, Receptors, Tocris Bioscience
