Biological Activity
Bcl-2 inhibitor (Ki values are 0.29 μM and 1.11 μM for Bcl-2 and Bcl-XL respectively). Inhibits the angiogenic potential of endothelial cells in vitro. Induces S-phase arrest and apoptosis in pancreatic cancer cell lines; also inhibits the activation of Notch-1 and Jagged-1 in vitro and in vivo.
Technical Data
| M. Wt | 573.7 |
| Formula | C33H35NO6S |
| Storage | Store at -20°C |
| Purity | ≥97% (HPLC) |
| CAS Number | 877877-35-5 |
| PubChem ID | 11455910 |
| InChI Key | PQAPVTKIEGUPRN-UHFFFAOYSA-N |
| Smiles | OC1=C(CC2=C(C(C)C)C=CC=C2)C=C(C(NC3=CC=C(S(C4=C(C(C)(C)C)C=CC=C4)(=O)=O)C=C3)=O)C(O)=C1O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 57.37 | 100 | |
| ethanol | 2.87 | 5 |
Preparing Stock Solutions
The following data is based on the product molecular weight 573.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.74 mL | 8.72 mL | 17.43 mL |
| 5 mM | 0.35 mL | 1.74 mL | 3.49 mL |
| 10 mM | 0.17 mL | 0.87 mL | 1.74 mL |
| 50 mM | 0.03 mL | 0.17 mL | 0.35 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Wang et al (2006) Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins. J.Med.Chem. 49 6139 PMID: 17034116
Zeitlin et al (2006) Antiangiogenic effect of TW37, a small-molecule inhibitor of Bcl-2. Cancer Res. 66 8698 PMID: 16951185
Ashimori et al (2009) TW-37, a small molecule inhibitor of Bcl-2, mediates S phase cell cycle arrest and suppresses head and neck tumor angiogenesis. Mol.Cancer.Ther. 8 893 PMID: 19372562
Wang et al (2009) TW-37, a small molecule inhibitor of Bcl-2, inhibits cell growth and induces apoptosis in pancreatic cancer: involvement of Notch-1 signaling pathway. Cancer Res. 69 2757 PMID: 19318573
Keywords: TW 37, supplier, bcl-2, inhibitors, inhibits, proapoptotic, apoptosis, inducers, TW37, Bcl-2, Family, Apoptosis, Inducers, Bcl-2, Family, Tocris Bioscience
