Biological Activity
Inhibitor of glycogen synthase kinase-3β (IC50 = 30 nM). Induces neuronal differentiation in pluripotent murine embryonal carcinoma cells and embryonic stem cells (ESCs).
Compound Libraries
TWS 119 is also offered as part of the Tocriscreen Plus and Tocriscreen Kinase Inhibitor Toolbox I. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 546.38 |
| Formula | C18H14N4O2.2CF3CO2H |
| Storage | Desiccate at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1507095-58-0 |
| PubChem ID | 90488884 |
| InChI Key | XJEFPMFFWJTJSL-UHFFFAOYSA-N |
| Smiles | FC(F)(F)C(O)=O.OC1=CC=CC(OC2=C3C(NC(C4=CC=CC(N)=C4)=C3)=NC=N2)=C1.FC(F)(F)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 54.64 | 100 | |
| ethanol | 54.64 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 546.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.83 mL | 9.15 mL | 18.3 mL |
| 5 mM | 0.37 mL | 1.83 mL | 3.66 mL |
| 10 mM | 0.18 mL | 0.92 mL | 1.83 mL |
| 50 mM | 0.04 mL | 0.18 mL | 0.37 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Ding et al (2003) Synthetic small molecules that control stem cell fate. Proc.Natl.Acad.Sci. 100 7632 PMID:
Kordes et al (2008) Canonical wnt signaling maintains the quiescent stage of hepatic stellate cells. Biochem.Biophys.Res.Comm. 367 116 PMID:
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