Biological Activity
Non-competitive AMPA/kainate receptor antagonist that displays 2.3-3-fold more potent activity than GYKI 52466 (Cat. No. 1454). Potentiates the anticonvulsive activity of antiepileptic drugs in animal models of seizures. Orally active.
Compound Libraries
Talampanel is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 337.37 |
| Formula | C19H19N3O3 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 161832-65-1 |
| PubChem ID | 164509 |
| InChI Key | JACAAXNEHGBPOQ-LLVKDONJSA-N |
| Smiles | NC(C=C4)=CC=C4C1=NN(C(C)=O)[C@H](C)CC2=C1C=C(OCO3)C3=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 33.74 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 337.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.96 mL | 14.82 mL | 29.64 mL |
| 5 mM | 0.59 mL | 2.96 mL | 5.93 mL |
| 10 mM | 0.3 mL | 1.48 mL | 2.96 mL |
| 50 mM | 0.06 mL | 0.3 mL | 0.59 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Czuczwar et al (1998) LY 300164, a novel antagonist of AMPA/kainate receptors, potentiates the anticonvulsive activity of antiepileptic drugs. Eur.J.Pharmacol. 359 103 PMID: 9832379
Borowicz et al (2000) The AMPA/kainate receptor antagonist, LY 300164, increases the anticonvulsant effects of diazepam. Naunyn-Schmied.Arch.Pharmacol. 361 629 PMID: 10882038
Belayev et al (2001) Talampanel, a novel noncompetitive AMPA antagonist, is neuroprotective after traumatic brain injury in rats. J.Neurotrauma 18 1031 PMID: 11686490
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