Biological Activity
Calcium-activated chloride channel (CaCC) (hCLCA1/mCLCA3) blocker; reduces mucin synthesis and release in cell culture and animal models. Possesses anti-inflammatory actions via inhibition of cyclooxygenases and inhibits Cl-/HCO3- exchanger activity. Increases survival in a cystic fibrosis mouse model of distal intestinal obstructive syndrome.
Compound Libraries
Talniflumate is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 414.34 |
| Formula | C21H13F3N2O4 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 66898-62-2 |
| PubChem ID | 48229 |
| InChI Key | ANMLJLFWUCQGKZ-UHFFFAOYSA-N |
| Smiles | FC(F)(F)C1=CC(NC2=NC=CC=C2C(=O)OC2OC(=O)C3=CC=CC=C23)=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 10.36 | 25 |
Preparing Stock Solutions
The following data is based on the product molecular weight 414.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.41 mL | 12.07 mL | 24.13 mL |
| 5 mM | 0.48 mL | 2.41 mL | 4.83 mL |
| 10 mM | 0.24 mL | 1.21 mL | 2.41 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.48 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Walker et al (2006) Talniflumate increases survival in a cystic fibrosis mouse model of distal intestinal obstructuve syndrome. J.Pharmacol.Exp.Ther. 317 275 PMID: 16354791
Sanchez et al (1982) Action of a non-steroidal anti-inflammatory drug on gastric mucosa of rats. J.Appl.Toxicol. 2 42 PMID:
Knight (2004) Talniflumate (Genaera). Curr.Opin.Invest.Drugs 5 557 PMID:
Keywords: Talniflumate, supplier, Cyclooxygenase, inhibitors, inhibits, chloride, channels, blockers, Chloride, hCLCA1/mCLCA3, COX, Oxygenases, Oxidases, Cl-/HCO3-, exchangers, CaCC, calcium-activated, Cyclooxygenase, Ca2+-Activated, Chloride, Channels, Ca2+-Activated, Chloride, Channels, Tocris Bioscience
