Biological Activity
Potent, selective inhibitor of the noradrenalin transporter (NET) (IC50 = 2.9 nM). Exhibits selectivity for NET against SERT (5-HT transporters) and DAT (dopamine transporters). Displays a similar structure but different pharmacological profile to citalopram (Cat. No. 1427).
Compound Libraries
Talopram hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 331.88 |
| Formula | C20H25NO.HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 7013-41-4 |
| PubChem ID | 71176 |
| InChI Key | JZXJIRQPHHWYGC-UHFFFAOYSA-N |
| Smiles | CC2(C)OC(C3=CC=CC=C3)(CCCNC)C1=CC=CC=C12.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 33.19 | 100 | |
| ethanol | 33.19 | 100 | |
| water | 16.59 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 331.88. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.01 mL | 15.07 mL | 30.13 mL |
| 5 mM | 0.6 mL | 3.01 mL | 6.03 mL |
| 10 mM | 0.3 mL | 1.51 mL | 3.01 mL |
| 50 mM | 0.06 mL | 0.3 mL | 0.6 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Bogeso et al (1985) 3-phenyl-1-indanamines. Potential antidepressant activity and potent inhibition of dopamine, norepinephrine, and serotonin uptake. J.Med.Chem. 28 1817 PMID: 2999402
Eildal et al (2008) From the selective serotonin transporter inhibitor citalopram to the selective norepinephrine transporter inhibitor talopram: synthesis and structure-activity relationship studies. J.Med.Chem. 51 3045 PMID: 18429609
Schou et al (2006) Synthesis and positron emission tomography evaluation of three norepinephrine transporter radioligands: [C-11]desipramine, [C-11]talopram and [C-11]talsupram. Mol.Imaging Biol. 8 1 PMID:
Keywords: Talopram hydrochloride, supplier, potent, selective, inhibitors, inhibits, noradrenalin, epinephrine, adrenergics, transporters, net, Lu3-010, noradrenaline, Lu, 3-010, Adrenergic, Transporters, Adrenergic, Transporters, Tocris Bioscience
