Biological Activity
Selective α1A-adrenoceptor antagonist (pKi values are 9.97, 9.64 and 8.86 for α1A, α1B and α1D subtypes respectively). Decreases resting maximal urethral pressure with negligable effect on mean arterial blood pressure in vivo.
Compound Libraries
Tamsulosin hydrochloride is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 444.97 |
| Formula | C20H28N2O5S.HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 106463-17-6 |
| PubChem ID | 5362376 |
| InChI Key | ZZIZZTHXZRDOFM-XFULWGLBSA-N |
| Smiles | C[C@@H](NCCOC2=CC=CC=C2OCC)CC1=CC=C(OC)C(S(=O)(N)=O)=C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 44.5 | 100 | |
| water | 4.45 | 10 |
Preparing Stock Solutions
The following data is based on the product molecular weight 444.97. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.25 mL | 11.24 mL | 22.47 mL |
| 5 mM | 0.45 mL | 2.25 mL | 4.49 mL |
| 10 mM | 0.22 mL | 1.12 mL | 2.25 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.45 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Garcia-Sainz et al (1995) Alpha 1-adrenoceptor subtype selectivity of tamsulosin: studies using livers from different species. Eur.J.Pharmacol. 289 1 PMID: 7781702
Taguchi et al (1997) Effects of tamsulosin metabolites at alpha-1 adrenoceptor subtypes. J.Pharmacol.Exp.Ther. 280 1 PMID: 8996174
Ohtake et al (2005) Effects of tamsulosin on resting urethral pressure and arterial blood pressure in anaesthetized female dogs. J.Pharm.Pharmacol. 58 345 PMID:
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