BiologicalActivity
mTORinhibitor;inhibitstumorgrowthinbreastcancercelllines(IC50valuesare1.6and4.3nMforSKBr3andBT474,respectively).InhibitsHIF-1α-mediatedVEGFproductioninbreastcancercelllines(BT474andMDA-MB-231).DirectlyinhibitsserumandVEGFmediatedendothelialcellproliferationandmorphogenesisinvitroandvesselformationinvivo.CausesG1/Scellcyclearrestinmultiplecancercelllines.Antiangiogenic.Activatesautophagy.
LicensingInformation
SoldforresearchpurposesunderagreementfromPfizerInc.
TechnicalData
| M.Wt | 1030.29 |
| Formula | C56H87NO16 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 162635-04-3 |
| PubChemID | 6918289 |
| InChIKey | CBPNZQVSJQDFBE-FUXHJELOSA-N |
| Smiles | O=C([C@H](C)C=C([C@@H](O)[C@@H](OC)C([C@@H]4C)=O)/C)C[C@]([C@H](C)C[C@H]2C[C@@H](OC)[C@H](OC(C(CO)(C)CO)=O)CC2)([H])OC([C@@]1([H])N(C(C([C@@]3(O)[C@H](C)CC[C@](C[C@@H](/C(C)=C/C=C/C=C/[C@H](C4)C)OC)([H])O3)=O)=O)CCCC1)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 103.03 | 100 | |
| ethanol | 103.03 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight1030.29.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 0.97mL | 4.85mL | 9.71mL |
| 5mM | 0.19mL | 0.97mL | 1.94mL |
| 10mM | 0.1mL | 0.49mL | 0.97mL |
| 50mM | 0.02mL | 0.1mL | 0.19mL |
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ProductDatasheets
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