Biological Activity
Blocker of Kir1.1 channels; displays >250-fold selectivity for Kir1.1 (Kd values are 1.1, 274 and 361 nM for Kir1.1, Kir3.1/3.2 and Kir3.1/3.4 respectively). Derivative of tertiapin-Q (Cat. No. 1316).
Technical Data
| M. Wt | 2428.03 |
| Formula | C106H179N33O24S4 |
| Sequence |
ALCNCNRIIIPLQCWKKCGKK (Modifications: Disulfide bridge between 3 - 14, 5 - 18, Lys-21 = C-terminal amide) |
| Storage | Store at -20°C |
| PubChem ID | 90488935 |
| InChI Key | WUMIWMIQOSXVPZ-ZPWFPUPGSA-N |
| Smiles | [H]N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]3CCCN3C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC3=CNC4=C3C=CC=C4)NC2=O)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 2 mg/ml in 20% acetonitrile / water |
Preparing Stock Solutions
The following data is based on the product molecular weight 2428.03. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.41 mL | 2.06 mL | 4.12 mL |
| 5 mM | 0.08 mL | 0.41 mL | 0.82 mL |
| 10 mM | 0.04 mL | 0.21 mL | 0.41 mL |
| 50 mM | 0.01 mL | 0.04 mL | 0.08 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Ramu et al (2008) Engineered specific and high-affinity inhibitor for a subtype of inward-rectifier K+ channels. Proc.Natl.Acad.Sci.USA 105 10774 PMID: 18669667
Keywords: Tertiapin LQ, supplier, TertiapinLQ, kir1.1, blockers, selective, venoms, inward, rectifier, potassium, channels, venoms, Inward, rectifier, Potassium, Channels, Inward, rectifier, Potassium, Channels, Tocris Bioscience
