BiologicalActivity
Ahighaffinityblockerforinward-rectifierK+channels,thiscompoundisastablederivativeofthebeevenomtoxintertiapin.BindstoROMK1(Kir1.1)andGIRK1/4(Kir3.1/3.4)channelswithhighaffinity(Kivaluesare1.3and13.3nMrespectively)andisselectiveoverKir2.1channels.DerivativetertiapinLQ(Cat.No.4339)alsoavailable.
LicensingInformation
SoldunderlicensegrantedbytheUniversityofPennsylvania
TechnicalData
| M.Wt | 2452 |
| Formula | C106H175N35O24S4 |
| Sequence | ALCNCNRIIIPHQCWKKCGKK (Modifications:Disulfidebridgebetween3-14,5-18,Lys-21=C-terminalamide) |
| Storage | Desiccateat-20°C |
| CASNumber | 910044-56-3 |
| PubChemID | 90479782 |
| InChIKey | GMZAXHIZSCRCHM-MIPBWYARSA-N |
| Smiles | [H]N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC3=CNC=N3)NC(=O)[C@@H]3CCCN3C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC3=CNC4=C3C=CC=C4)NC2=O)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solubility | Solubleto2mg/mlinwater |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight2452.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 0.41mL | 2.04mL | 4.08mL |
| 5mM | 0.08mL | 0.41mL | 0.82mL |
| 10mM | 0.04mL | 0.2mL | 0.41mL |
| 50mM | 0.01mL | 0.04mL | 0.08mL |
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