BiologicalActivity
Potentinhibitorofvesicularmonoamineuptake;depletesstoresofdopamine,SEROtoninandnoradrenalin.Bindswithhighaffinity(IC50=3.2nM)tovesicularmonoaminetransporter(VMAT)inchromaffingranulemembranesanddisplayshigheraffinityforVMAT2thanVMAT1.Alsoreportedtoblockdopaminereceptors.Causesbehavioraldepression;inhibitslocomotoractivityandproduceshypothermiauponsystemicadmiNISTrationinratsandmice.
CompoundLibraries
TetrabenazineisalsoofferedaspartoftheTocriscreenPlusandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 317.2 |
| Formula | C19H27NO3 |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 58-46-8 |
| PubChemID | 11634155 |
| InChIKey | MKJIEFSOBYUXJB-HOCLYGCPSA-N |
| Smiles | O=C3[C@@H](CC(C)C)CN2CCC1=CC(OC)=C(OC)C=C1[C@@]([H])2C3 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 31.74 | 100 | |
| ethanol | 9.52 | 30 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight317.2.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.15mL | 15.76mL | 31.53mL |
| 5mM | 0.63mL | 3.15mL | 6.31mL |
| 10mM | 0.32mL | 1.58mL | 3.15mL |
| 50mM | 0.06mL | 0.32mL | 0.63mL |
MolarityCalculator
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ProductDatasheets
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