Biological Activity
Potent NMDA receptor agonist, approximately 20 times more active than NMDA. Also available as part of the Mixed NMDA Receptor Tocriset™.
Technical Data
| M. Wt | 143.1 |
| Formula | C3H5N5O2 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 138199-51-6 |
| PubChem ID | 126383 |
| InChI Key | UKBRUIZWQZHXFL-UHFFFAOYSA-N |
| Smiles | NC(C(O)=O)C1=NN=NN1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 50 mM in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 143.1. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 6.99 mL | 34.94 mL | 69.88 mL |
| 5 mM | 1.4 mL | 6.99 mL | 13.98 mL |
| 10 mM | 0.7 mL | 3.49 mL | 6.99 mL |
| 50 mM | 0.14 mL | 0.7 mL | 1.4 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Arnt et al (1995) Diffentiation of in vivo effects of AMPA and NMDA receptor ligands using drug discrimination methods and convulsant/anticonvulsant activity. Eur.J.Pharmacol. 285 289 PMID: 8575516
Moroni et al (1995) NMDA receptor heterogeneity in mammalian tissues: focus on two agonists, (2S,3R,4S)cyclopropylglutamate and the sulfate ester of 4-hydroxy-(S)-pipecolic acid. Naunyn Schmiedebergs Arch.Pharmacol. 351 371 PMID: 7543185
Schoepp et al (1991) D,L-(Tetrazol-5-yl)glycine a novel and highly potent NMDA receptor agonist. Eur.J.Pharmacol. 203 237 PMID: 1686860
Keywords: (RS)-(Tetrazol-5-yl)glycine, supplier, potent, NMDA, receptor, agonists, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, NMDA, Receptors, NMDA, Receptors, Tocris Bioscience
