Biological Activity
Potent and selective Nav1.6 channel blocker (IC50 values are 7.8, 341, 988, 1260, 1270, 78500 and >30000 nM for Nav1.6, Nav1.3, Nav1.4, Nav1.2, Nav1.7, Nav1.5 and Nav1.8). Derivative of tetrodotoxin (Cat. No. 1078).
Technical Data
| M. Wt | 301.25 |
| Formula | C11H15N3O7 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 13072-89-4 |
| PubChem ID | 11243537 |
| InChI Key | STNXQECXKDMLJK-PZKHIREQSA-N |
| Smiles | O[C@@]1(CO)[C@H](O2)[C@H]([C@H](O3)NC(N4[H])=N)[C@]54[C@H]3[C@@]2(O)O[C@H]1[C@H]5O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 1 | 4 |
Preparing Stock Solutions
The following data is based on the product molecular weight 301.25. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.32 mL | 16.6 mL | 33.2 mL |
| 5 mM | 0.66 mL | 3.32 mL | 6.64 mL |
| 10 mM | 0.33 mL | 1.66 mL | 3.32 mL |
| 50 mM | 0.07 mL | 0.33 mL | 0.66 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Rosker et al (2007) The TTX metabolite 4,9-anhydro-TTX is a highly specific blocker of the Nav1.6 voltage-dependent sodium channel. Am.J.Physiol.Cell Physiol. 293 C783 PMID: 17522141
Hargus et al (2013) Evidence for a role of Nav1.6 in facilitating increases in neuronal hyperexcitability during epileptogenesis J.Neurophysiol 110 1144 PMID: 23741036
Keywords: 4,9-Anhydrotetrodotoxin, supplier, Na+, channel, blockers, Sodium, Nav, 1.6, channels, voltage-gated, voltage-dependent, potent, selective, 4,9-anhydro-TTX, Voltage-gated, Sodium, Channels, Voltage-gated, Sodium, Channels, Tocris Bioscience
