Biological Activity
Amino acid analog of glutamine and component of green tea. Shown to bind to AMPA, Kainate, NMDA and group I mGlu receptors. Displays neuroprotective effects in vivo. Promotes self-renewal of human embryonic stem cells (hESC).
Technical Data
| M. Wt | 174.2 |
| Formula | C7H14N2O3 |
| Storage | Store at RT |
| CAS Number | 3081-61-6 |
| PubChem ID | 439378 |
| InChI Key | DATAGRPVKZEWHA-YFKPBYRVSA-N |
| Smiles | CCNC(CC[C@H](N)C(O)=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 17.42 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 174.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5.74 mL | 28.7 mL | 57.41 mL |
| 5 mM | 1.15 mL | 5.74 mL | 11.48 mL |
| 10 mM | 0.57 mL | 2.87 mL | 5.74 mL |
| 50 mM | 0.11 mL | 0.57 mL | 1.15 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Kakuda et al (2002) Inhibition by theanine of binding of [3H]AMPA, [3H]kainate, and [3H]MDL 105,519 to glutamate receptors. Biosci.Biotechnol.Biochem. 66 2683 PMID: 12596867
Egashira et al (2008) Theanine prevents memory impairment induced by repeated cerebral ischemia in rats. Phytother.Res. 22 65 PMID: 17705146
Desbordes et al (2008) High-throughput screening assay for the identification of compounds regulating self-renewal and differentiation in human embryonic stem cells. Cell Stem Cell. 2 602 PMID: 18522853
Nagasawa et al (2004) Possible involvement of group I mGluRs in neuroprotective effect of theanine. Biochem.Biophys.Res.Comm. 320 116 PMID:
Keywords: Theanine, supplier, glutamate, glutamine, analogue, receptors, metabotropic, mGlu, NMDA, Kainate, AMPA, ligands, hESC, human, embryonic, stem, cells, Miscellaneous, Glutamate, Stem, Cell, Proliferation, Miscellaneous, Glutamate, Tocris Bioscience
