Biological Activity
Dopamine receptor antagonist that displays antipsychotic activity. Exhibits anticancer activity in cervical, endometrial and breast cancer cells; triggers apoptosis by targeting the PI 3-K/Akt/mTOR/p70 S6K pathway. Induces G1 cell cycle arrest. Selective inducer of cancer stem cell (CSC) differentiation.
Compound Libraries
Thioridazine hydrochloride is also offered as part of the Tocriscreen Stem Cell Toolbox. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 407.04 |
| Formula | C21H26N2S2.HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 130-61-0 |
| PubChem ID | 66062 |
| InChI Key | NZFNXWQNBYZDAQ-UHFFFAOYSA-N |
| Smiles | CN(CCCC4)C4CCN2C3=C(C=CC(SC)=C3)SC1=CC=CC=C12.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 40.7 | 100 | |
| ethanol | 20.35 | 50 | |
| water | 30.53 | 75 |
Preparing Stock Solutions
The following data is based on the product molecular weight 407.04. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.46 mL | 12.28 mL | 24.57 mL |
| 5 mM | 0.49 mL | 2.46 mL | 4.91 mL |
| 10 mM | 0.25 mL | 1.23 mL | 2.46 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.49 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Merck Index 13 9435 PMID:
Sachlos et al (2012) Identification of drugs including a dopamine receptor antagonist that selectively target cancer stem cells. Cell. May 23. Epub ahead of print PMID: 22632761
Kang et al (2012) Thioridazine induces apoptosis by targeting the PI3K/Akt/mTOR pathway in cervical and endometrial cancer cells. Apoptosis. Mar 30 Epub ahead of print PMID: 22460505
Keywords: Thioridazine hydrochloride, supplier, Dopamine, receptor, antagonists, antipsychotic, D2-like, Non-Selective, Receptors, dopaminergic, anticancer, Non-selective, Dopamine, Cancer, Stem, Cells, Cancer, Stem, Cell, Differentiation, Non-selective, Dopamine, Tocris Bioscience
