Biological Activity
Agonist at the thrombin receptor; causes platelet aggregation (EC50 = 4 μM) and secretion.
Technical Data
| M. Wt | 1739 |
| Formula | C81H118N20O23 |
| Sequence | SFLLRNPNDKYEPF |
| Storage | Desiccate at -20°C |
| CAS Number | 137339-65-2 |
| PubChem ID | 16131180 |
| InChI Key | OXHYRVSBKWIFES-WWSDOYNLSA-N |
| Smiles | [H]N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCC(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=CC=C1)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 0.90 mg/ml in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 1739. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.58 mL | 2.88 mL | 5.75 mL |
| 5 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 10 mM | 0.06 mL | 0.29 mL | 0.58 mL |
| 50 mM | 0.01 mL | 0.06 mL | 0.12 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Huang et al (1991) 'Thrombin' receptor-directed ligand accounts for activation by thrombin of platelet phospholipase C and accumulation of 3-phosphorylated phosphoinositides. J.Biol.Chem. 266 18435 PMID: 1655750
Vassallo et al (1992) Structure-function relationships in the activation of platelet thrombin receptors by receptor-derived peptides. J.Biol.Chem. 267 6081 PMID: 1313429
Vu et al (1991) Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell 64 1057 PMID: 1672265
Keywords: Thrombin Receptor Agonist Peptide, supplier, Causes, platelet, aggregation, secretion, PAR, Receptors, Protease-Activated, thrombin, receptor, agonists, TRAP, Protease-Activated, Receptors, Protease-Activated, Receptors, Tocris Bioscience
