Biological Activity
Selective P2Y12 receptor antagonist. Inhibits ADP-induced platelet aggregation and displays antithrombotic activity following oral administration in vivo.
Technical Data
| M. Wt | 300.25 |
| Formula | C14H14ClNS.HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 53885-35-1 |
| PubChem ID | 65335 |
| InChI Key | MTKNGOHFNXIVOS-UHFFFAOYSA-N |
| Smiles | ClC(C=CC=C3)=C3CN1CCC2=C(C=CS2)C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 30.02 | 100 | |
| ethanol | 22.52 | 75 | |
| water | 30.02 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 300.25. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.33 mL | 16.65 mL | 33.31 mL |
| 5 mM | 0.67 mL | 3.33 mL | 6.66 mL |
| 10 mM | 0.33 mL | 1.67 mL | 3.33 mL |
| 50 mM | 0.07 mL | 0.33 mL | 0.67 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Michelson (2008) P2Y12 antagonism: promises and challenges. Arterioscler.Thromb.Vasc.Biol. 28 33 PMID:
Savi and Herbert (2005) Clopidogrel and ticlopidine: P2Y12 adenosine diphosphate-receptor antagonists for the prevention of atherothrombosis. Semin.Thromb.Haemostas. 31 174 PMID:
Sharis et al (1998) The antiplatelet effects of ticlopidine and clopidogrel. Ann.Int.Med. 129 394 PMID:
Keywords: Ticlopidine hydrochloride, supplier, selective, P2Y12, purinergic, receptors, purinoceptors, antagonists, Purinergic, P2Y, Receptors, Purinergic, P2Y, Receptors, Tocris Bioscience
