Biological Activity
Potent and selective breast tumor kinase (Brk, also known as tyrosine-protein kinase 6, PTK6) inhibitor (IC50 = 3.15 nM). Exhibits >1000-fold selectivity for Brk over a panel of other kinases. Inhibits proliferation of breast cancer cells in vitro.
Licensing Information
Sold under license from Martin-Luther-Universität-Halle-Wittenburg
Technical Data
| M. Wt | 275.3 |
| Formula | C17H13N3O |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1600515-49-8 |
| PubChem ID | 76332983 |
| InChI Key | RXPZOSHFGJWSLQ-UHFFFAOYSA-N |
| Smiles | OC1=CC=CC(NC2=C3C(NC4=CC=CC=C43)=NC=C2)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 27.53 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 275.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.63 mL | 18.16 mL | 36.32 mL |
| 5 mM | 0.73 mL | 3.63 mL | 7.26 mL |
| 10 mM | 0.36 mL | 1.82 mL | 3.63 mL |
| 50 mM | 0.07 mL | 0.36 mL | 0.73 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Mahmoud et al (2014) Discovery of 4-anilino α-carbolines as novel Brk inhibitors. Bioorg.Med.Chem.Lett. 24 1948 PMID: 24650640
Keywords: Tilfrinib, supplier, potent, selective, breast, tumor, kinases, Brk, antiproliferative, cancer, tyrosine-protein, kinases, 6, TK6, inhibitors, inhibits, Src, Kinases, Src, Kinases, Tocris Bioscience
