Biological Activity
Potent histamine H2-receptor antagonist with negligible activity against H1- and H3- receptors.
Licensing Information
Sold with the permission of AstraZeneca UK Ltd.
Compound Libraries
Tiotidine is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 312.41 |
| Formula | C10H16N8S2 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 69014-14-8 |
| PubChem ID | 50287 |
| InChI Key | YDDXVAXDYKBWDX-UHFFFAOYSA-N |
| Smiles | CNC(NCCSCC1=CSC(N=C(/N)N)=N1)=N/C#N |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 10 mM in ethanol and to 100 mM in DMSO |
Preparing Stock Solutions
The following data is based on the product molecular weight 312.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.2 mL | 16 mL | 32.01 mL |
| 5 mM | 0.64 mL | 3.2 mL | 6.4 mL |
| 10 mM | 0.32 mL | 1.6 mL | 3.2 mL |
| 50 mM | 0.06 mL | 0.32 mL | 0.64 mL |
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References
References are publications that support the products' biological activity.
Hill (1990) Distribution, properties, and functional characteristics of three classes of histamine receptor. Pharmacol.Rev. 42 45 PMID: 2164693
Trzeciakowski and Levi (1980) The cardiac pharmacology of tiotidine (ICI 125,211): A new histamine H2- receptor antagonist. J.Pharmacol.Exp.Ther. 214 629 PMID: 6105207
Yellin et al (1979) ICI 125,211: A new gastric antisecretory agent acting on histamine H2- receptors. Life Sci. 25 2001 PMID: 43449
Keywords: Tiotidine, supplier, Potent, selective, H2, antagonists, Receptors, Histamine, histaminergic, AstraZeneca, ICI125211, ICI, 125,211, Histamine, H2, Receptors, Histamine, H2, Receptors, Tocris Bioscience
