Biological Activity
α2-adrenergic receptor agonist. Antinociceptive upon epidural administration in rats (IC50 = 48 nM). Also binds to imidazoline receptor.
Compound Libraries
Tizanidine hydrochloride is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 290.17 |
| Formula | C9H8ClN5S.HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 64461-82-1 |
| PubChem ID | 114869 |
| InChI Key | ZWUKMNZJRDGCTQ-UHFFFAOYSA-N |
| Smiles | ClC2=C(NC3=NCCN3)C1=NSN=C1C=C2.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 29.02 | 100 | |
| water | 29.02 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 290.17. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.45 mL | 17.23 mL | 34.46 mL |
| 5 mM | 0.69 mL | 3.45 mL | 6.89 mL |
| 10 mM | 0.34 mL | 1.72 mL | 3.45 mL |
| 50 mM | 0.07 mL | 0.34 mL | 0.69 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Asano et al (2000) Antinociception by epidural and systemic α2-adrenoceptor agonists and their binding affinity in rat spinal cord and brain. Anesth.Analg. 90 400 PMID: 10648329
Piletz et al (2000) Autoradiographic comparison of [3H]-Clonidine binding to non-adrenergic sites and α2-adrenergic receptors in human brain. Neuropsychopharmacology 23 697 PMID: 11063925
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