BiologicalActivity
Anticonvulsant.AntagonizesGluR5kainatereceptors(IC50=0.46μM),actsasapositiveallostericmodulatorofGABAAreceptor-mediatedcurrents,inhibitsNavchannels(IC50=48.9μM)andinhibitsL-typeCa2+channels.Alsoinhibitscarbonicanhydrase(CA)(Kivaluesare0.1and0.2μMatratCAIIandCAIVrespectively),whichlowersintracellularneuronalpH.
CompoundLibraries
TopiramateisalsoofferedaspartoftheTocriscreenPlusandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 339.36 |
| Formula | C12H21NO8S |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 97240-79-4 |
| PubChemID | 5284627 |
| InChIKey | KJADKKWYZYXHBB-XBWDGYHZSA-N |
| Smiles | CC(O2)(C)O[C@H]1[C@@H]2[C@H](OC(C)(C)O3)[C@@]3(COS(N)(=O)=O)OC1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 33.94 | 100 | |
| ethanol | 33.94 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight339.36.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.95mL | 14.73mL | 29.47mL |
| 5mM | 0.59mL | 2.95mL | 5.89mL |
| 10mM | 0.29mL | 1.47mL | 2.95mL |
| 50mM | 0.06mL | 0.29mL | 0.59mL |
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ProductDatasheets
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