Biological Activity
Subtype-selective GABAA receptor modulator. Can potentiate or inhibit recombinant GABAA function depending on subunit combination. Enhances native GABAA receptor function and is anxiolytic following systemic administration in vivo.
Technical Data
M. Wt | 340.85 |
Formula | C16H24N4O2.HCl |
Storage | Desiccate at RT |
Purity | ≥99% (HPLC) |
CAS Number | 1135210-68-2 |
PubChem ID | 24871267 |
InChI Key | TUIXDPUEMQXVHO-UHFFFAOYSA-N |
Smiles | Cl.CCCCNC1=C2C=NN(CC)C2=NC(C)=C1C(=O)OCC |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
1eq. HCl | 34.09 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 340.85. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 2.93 mL | 14.67 mL | 29.34 mL |
5 mM | 0.59 mL | 2.93 mL | 5.87 mL |
10 mM | 0.29 mL | 1.47 mL | 2.93 mL |
50 mM | 0.06 mL | 0.29 mL | 0.59 mL |
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References
References are publications that support the products' biological activity.
Meiners and Salama (1982) Enhancement of benzodiazepine and GABA binding by the novel anxiolytic, tracazolate. Eur.J.Pharmacol. 78 315 PMID: 6121710
Patel and Malick (1982) Pharmacological properties of tracazolate: a new non-benzodiazepine anxiolytic agent. Eur.J.Pharmacol. 78 323 PMID: 6121711
Thompson et al (2002) Tracazolate reveals a novel type of allosteric interaction with recombinant γ-aminobutyric acidA receptors. Mol.Pharmacol. 61 861 PMID: 11901225
Keywords: Tracazolate hydrochloride, supplier, Subtype-selective, GABAA, allosteric, modulators, Receptors, ICI136753, ICI, 136753, GABAA, Receptors, GABAA, Receptors, Tocris Bioscience