Biological Activity
Potent prostacyclin (PGI2) analog (EC50 values are 0.6, 1.9 and 6.2 nM at DP1, IP and EP2 receptors respectively). Causes vasodilation of human pulmonary arteries and inhibits NFκB nuclear translocation in human alveolar macrophages in vitro.
Technical Data
| M. Wt | 390.51 |
| Formula | C23H34O5 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 81846-19-7 |
| PubChem ID | 6918140 |
| InChI Key | PAJMKGZZBBTTOY-ZFORQUDYSA-N |
| Smiles | O[C@H](C3)[C@H](CC[C@@H](O)CCCCC)[C@@]([C@@]3([H])C2)([H])CC1=C2C(OCC(O)=O)=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.05 | 100 | |
| ethanol | 19.53 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 390.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.56 mL | 12.8 mL | 25.61 mL |
| 5 mM | 0.51 mL | 2.56 mL | 5.12 mL |
| 10 mM | 0.26 mL | 1.28 mL | 2.56 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.51 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Whittle et al (2012) Binding and activity of the prostacyclin receptor (IP) agonists, treprostinil and iloprost, at human prostanoid receptors: treprostinil is a potent DP1 and EP2 agonist. Biochem.Pharmacol. 84 68 PMID: 22480736
Raychaudhuri et al (2002) The prostacyclin analogue treprostinil blocks NFκB nuclear translocation in human alveolar macrophages. J.Biol.Chem. 277 33344 PMID: 12082102
Fontana et al (2007) Treprostinil potentiates the positive inotropic effect of catecholamines in adult rat ventricular cardiomyocytes. Br.J.Pharmacol. 151 779 PMID: 17533419
Keywords: Treprostinil, supplier, Potent, prostacyclin, PGI2, analogues, DP,IP, EP2, agonists, agonism, vasodilation, pulmonary, hypertension, PPH, Prostanoid, Receptors, Prostanoid, Receptors, Tocris Bioscience
