Biological Activity
Selective and potent inhibitor of histone deacetylase (Ki = 3.4 nM). Active in vivo. Potential anti-cancer agent. Induces accelerated dedifferentiation of primordial germ cells (PGCs) into embryonic germ (EG) cells. Activates autophagy.
Technical Data
| M. Wt | 302.37 |
| Formula | C17H22N2O3 |
| Storage | Desiccate at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 58880-19-6 |
| PubChem ID | 444732 |
| InChI Key | RTKIYFITIVXBLE-QEQCGCAPSA-N |
| Smiles | O=C([C@H](C)/C=C(C)/C=C/C(NO)=O)C1=CC=C(N(C)C)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 15.12 | 50 | |
| ethanol | 3.02 | 10 |
Preparing Stock Solutions
The following data is based on the product molecular weight 302.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.31 mL | 16.54 mL | 33.07 mL |
| 5 mM | 0.66 mL | 3.31 mL | 6.61 mL |
| 10 mM | 0.33 mL | 1.65 mL | 3.31 mL |
| 50 mM | 0.07 mL | 0.33 mL | 0.66 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Durcova-Hills et al (2008) Reprogramming primordial germ cells into pluripotent stem cells. PloS ONE 3 e3531 PMID: 18953407
Yoshida et al (1990) Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A. J.Biol.Chem. 265 17174 PMID: 2211619
Vigushin et al (2001) Trichostatin A is a histone deacetylase inhibitor with potent antitumor activity against breast cancer in vivo. Clin.Cancer Res. 7 971 PMID: 11309348
Wharton et al (2000) Inhibition of mitogenesis in Balb/c-3T3 cells by trichostatin A. J.Biol.Chem. 275 33981 PMID: 10945992
Galluzzi et al (2017) Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles. Nat.Rev.Drug.Discov. PMID: 28529316
Keywords: Trichostatin A, supplier, Histone, deacetylase, inhibitors, inhibits, HDAC, Deacetylases, TrichostatinA, stem, cells, epigenetics, Histone, Deacetylases, Reprogramming, Autophagy, Histone, Deacetylases, Tocris Bioscience
