BiologicalActivity
InhibitsDNA-dependentATPaseactivityofXBPandinducesinhibitionofRNApolymeraseII(RNAPII)-mediatedtranscription(IC50=200nM).SelectiveforRNAPIIoverRNAPIandRNAPIII.BlocksRNAsynthesisinHeLacells(IC50=62nM);exhibitspotentantiproliferativeactivityin60cancercelllines(averageIC50=12nM)andinducesapoptosisbyblockingTNF-α-mediatedc-IAP1andc-IAP2induction.Alsodisplaysimmunosuppressiveandanti-inflammatoryactivity.
CompoundLibraries
TriptolideisalsoofferedaspartoftheTocriscreenPlusandTocriscreenEpigeneticsToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 360.4 |
| Formula | C20H24O6 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 38748-32-2 |
| PubChemID | 107985 |
| InChIKey | DFBIRQPKNDILPW-CIVMWXNOSA-N |
| Smiles | O=C1C2=C([C@@](C[C@H]5[C@]4(O5)[C@](O6)3[C@@H]6[C@H]7[C@](C(C)C)(O7)[C@H]4O)([H])[C@]3(C)CC2)CO1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 7.21 | 20 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight360.4.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.77mL | 13.87mL | 27.75mL |
| 5mM | 0.55mL | 2.77mL | 5.55mL |
| 10mM | 0.28mL | 1.39mL | 2.77mL |
| 50mM | 0.06mL | 0.28mL | 0.55mL |
MolarityCalculator
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ProductDatasheets
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