Biological Activity
Selective PPARγ receptor agonist (EC50 values are 780 and 555 nM at murine and human PPARγ receptors respectively). Displays no activity at PPARα or PPARδ receptors. Antidiabetic agent; exerts potent glucose-lowering effects in insulin-resistant diabetic mice. Displays anti-invasive effect on human breast cancer cells; reduces migration, adhesion and spreading on fibronectin-coated plates. Also inhibits cell growth of hematopoietic cell lines. Inhibits lamellipodia formation and actin polymerization.
Compound Libraries
Troglitazone is also offered as part of the Tocriscreen Plus and Tocriscreen Stem Cell Toolbox. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 441.54 |
| Formula | C24H27NO5S |
| Storage | Store at -20°C |
| Purity | ≥97% (HPLC) |
| CAS Number | 97322-87-7 |
| PubChem ID | 5591 |
| InChI Key | GXPHKUHSUJUWKP-UHFFFAOYSA-N |
| Smiles | CC1=C2C(CCC(COC3=CC=C(CC4C(NC(S4)=O)=O)C=C3)(C)O2)=C(C)C(O)=C1C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 44.15 | 100 | |
| ethanol | 4.42 | 10 |
Preparing Stock Solutions
The following data is based on the product molecular weight 441.54. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.26 mL | 11.32 mL | 22.65 mL |
| 5 mM | 0.45 mL | 2.26 mL | 4.53 mL |
| 10 mM | 0.23 mL | 1.13 mL | 2.26 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.45 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Lee and Olefsky (1995) Acute effects of troglitazone on in vivo insulin action in normal rats. Metabolism 44 1166 PMID: 7666790
Kodera et al (2000) Ligand type-specific interactions of peroxisome-proliferator-activated receptor γ with transcriptional coactivators. J.Biol.Chem. 275 33201 PMID: 10944516
Willson et al (2000) The PPARs: from orphan receptors to drug discovery. J.Med.Chem. 43 527 PMID: 10691680
Fujimura et al (1998) Effects of troglitazone on the growth and differentiation of hematopoietic cell lines. Int.J.Oncol. 13 1263 PMID: 9824642
Keywords: Troglitazone, supplier, Selective, PPARγ, PPARgamma, agonists, antidiabetic, agent, Peroxisome, Proliferator-activating, Receptors, Rezulin, PPARgamma, Receptors, Stem, Cell, Proliferation, PPARgamma, Receptors, Tocris Bioscience
