BiologicalActivity
Fluoroquinoloneantibiotic.InhibitsbacterialDNAtopoisomeraseIVandDNAgyraseandformsastablequinolone-DNAcomplexwiththeseenzymeswhichreversIBLyinhibitsDNAsynthesis.Displayspotentactivityagainstgram-positiveandgram-negativebacteria.IncreasestheproductionofmitochondrialNOinimmortalizedhepatocytes;alsoincreasesmitochondrialCa2+.InhibitsPanx-1(IC50~4μM).
LicensingInformation
SoldforresearchpurposesunderagreementfromPfizerInc.
CompoundLibraries
TrovafloxacinmesylateisalsoofferedaspartoftheTocriscreenPlusandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 512.46 |
| Formula | C20H15F3N4O3.CH3SO3H |
| Storage | DesiccateatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 147059-75-4 |
| PubChemID | 62960 |
| InChIKey | DYNZICQDCVYXFW-GIPYJWDTSA-N |
| Smiles | O=C2C1=CC(F)=C(N4C[C@@]([C@H]5N)([H])[C@@]5([H])C4)N=C1N(C3=C(F)C=C(F)C=C3)C=C2C(O)=O.CS(=O)(O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 51.25 | 100 | |
| water | 25.62 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight512.46.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.95mL | 9.76mL | 19.51mL |
| 5mM | 0.39mL | 1.95mL | 3.9mL |
| 10mM | 0.2mL | 0.98mL | 1.95mL |
| 50mM | 0.04mL | 0.2mL | 0.39mL |
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ProductDatasheets
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