Biological Activity
Competitive, non-selective nicotinic acetylcholine receptor antagonist; causes skeletal muscle relaxation. Also a 5-HT3 and GABAA receptor antagonist.
Technical Data
| M. Wt | 681.65 |
| Formula | C37H41ClN2O6.HCl |
| Storage | Desiccate at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 57-94-3 |
| PubChem ID | 64645 |
| InChI Key | GXFZCDMWGMFGFL-KKXMJGKMSA-N |
| Smiles | OC1=C(OC)C=C3C([C@@H]7[N+](C)(C)CC3)=C1OC(C=C5)=CC=C5C[C@H](N(C)CC4)C2=C4C=C(OC)C(OC6=C(O)C=CC(C7)=C6)=C2.[Cl-].Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 6.82 | 10 | |
| water | 17.04 | 25 |
Preparing Stock Solutions
The following data is based on the product molecular weight 681.65. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.47 mL | 7.34 mL | 14.67 mL |
| 5 mM | 0.29 mL | 1.47 mL | 2.93 mL |
| 10 mM | 0.15 mL | 0.73 mL | 1.47 mL |
| 50 mM | 0.03 mL | 0.15 mL | 0.29 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Pederson and Cohen (1990) d-Tucocurarine binding sites are located at α-γ and α-δ subunit interfaces of the nicotinic acetylcholine receptor. Proc.Natl.Acad.Sci.USA 87 2785 PMID:
Peters et al (1990) Antagonism of 5-HT3 receptor mediated currents in murine N1E-115 neuroblastoma cells by (+)-tubocurarine. Neurosci.Letts. 110 107 PMID:
Wotring and Yoon (1995) The inhibitory effects of nicotinic antagonists on currents elicited by GABA in rat hippocampal neurons. Neurosci. 67 293 PMID:
Keywords: (+)-Tubocurarine chloride, supplier, Nicotinic, receptor, antagonists, Acetylcholine, Receptors, Non-Selective, Subtypes, nAChR, curare, Nicotinic, Receptors, (Non-selective), Nicotinic, Receptors, (Non-selective), Tocris Bioscience
