Biological Activity
Epidermal growth factor receptor (EGFR) kinase inhibitor (IC50 = 0.86 μM). Slightly less active than the (-) enantiomer (Cat. No. 0578).
Technical Data
| M. Wt | 308.34 |
| Formula | C18H16N2O3 |
| Storage | Desiccate at +4°C |
| CAS Number | 133550-37-5 |
| PubChem ID | 5328769 |
| InChI Key | UMGQVUWXNOJOSJ-DGGAMASNSA-N |
| Smiles | OC1=C(O)C=CC(C=C(C(N[C@@H](C)C2=CC=CC=C2)=O)/C#N)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 9.25 | 30 |
Preparing Stock Solutions
The following data is based on the product molecular weight 308.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.24 mL | 16.22 mL | 32.43 mL |
| 5 mM | 0.65 mL | 3.24 mL | 6.49 mL |
| 10 mM | 0.32 mL | 1.62 mL | 3.24 mL |
| 50 mM | 0.06 mL | 0.32 mL | 0.65 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Gazit et al (1991) Tyrphostins. 2. Heterocyclic and α-substituted benzylidenemalononitrile tyrophostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases. J.Med.Chem. 34 1896 PMID: 1676428
Keywords: Tyrphostin B44, (+) enantiomer, supplier, EGFR, kinase, inhibitors, inhibits, Epidermal, Growth, Factor, Receptors, ErbB, Her, RTK, Receptor, Tyrosine, Kinases, RTKs, (+)-TyrphostinB44, EGFR, EGFR, Tocris Bioscience
