Biological Activity
PGH2 (TXA2) analog that is a potent and stable thromboxane A2 (TP) receptor agonist (EC50 = 0.035 μM). Potently stimulates TP receptor-mediated, but not other prostaglandin receptor-mediated responses in various in vitro preparations. Activates ERK-1 and ERK-2 in HEK 293 cells expressing TPα and TPβ receptors.
Technical Data
| M. Wt | 350.5 |
| Formula | C21H34O4 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 56985-40-1 |
| PubChem ID | 5311493 |
| InChI Key | LQANGKSBLPMBTJ-BRSNVKEHSA-N |
| Smiles | O[C@@H](CCCCC)/C=C/[C@H]1[C@@H]2OC[C@@H](C2)[C@@H]1C/C=CCCCC(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble in methyl acetate (supplied pre-dissolved -10mg/ml) |
Preparing Stock Solutions
The following data is based on the product molecular weight 350.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.85 mL | 14.27 mL | 28.53 mL |
| 5 mM | 0.57 mL | 2.85 mL | 5.71 mL |
| 10 mM | 0.29 mL | 1.43 mL | 2.85 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.57 mL |
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References
References are publications that support the products' biological activity.
Coleman et al (1981) Comparison of the actions of U-46619, a prostaglandin H2-analogue, with those of prostaglandin H2 and thromboxane A2 on some isolated smooth muscle preparations. Br.J.Pharmacol. 73 773 PMID: 7248665
Morinelli et al (1987) Receptor-mediated effects of a PGH2 analogue (U 46619) on human platelets. Am.J.Physiol. 253 H1035 PMID: 3688248
Miggin and Kinsella (2002) Regulation of extracellular signal-regulated kinase cascades by α- and β-isoforms of the human thromboxane A2 receptor. Mol.Pharmacol. 61 817 PMID: 11901221
Keywords: U 46619, supplier, Potent, stable, thromboxane, A2, TP, receptor, agonists, TXA2, Prostanoid, prostaglandins, prostacyclins, eicosanoids, U46619, 9, 11-Dideoxy-9a, 11a-methanoepoxy, prostaglandinF2a, 9,11-Dideoxy-9a,11a-methanoepoxy, prostaglandin, F2a, Prostanoid, Receptors, Prostanoid, Receptors, Tocris Bioscience
