Biological Activity
GABAA receptor ligand that binds with comparable affinities to three receptor subtypes: α1β2γ2, α3β2γ2 and α6β2γ2 (Ki values are 7.8, 9.5 and 11.0 nM respectively). Potentiates GABA-induced chloride currents in α6β2γ2 receptors. Sedative/hypnotic compound.
Technical Data
| M. Wt | 352.78 |
| Formula | C17H13ClN6O |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 134516-99-7 |
| PubChem ID | 9928470 |
| InChI Key | CLPSAAPUJUVQPP-UHFFFAOYSA-N |
| Smiles | ClC1=CC=C4C(C2=NCCN2C(N4C=N5)=C5C3=NOC(C6CC6)=N3)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 10.58 | 30 | |
| ethanol | 1.76 | 5 |
Preparing Stock Solutions
The following data is based on the product molecular weight 352.78. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.83 mL | 14.17 mL | 28.35 mL |
| 5 mM | 0.57 mL | 2.83 mL | 5.67 mL |
| 10 mM | 0.28 mL | 1.42 mL | 2.83 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.57 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Tang et al (1995) U-90042, a sedative/hypnotic compound that interacts differentially with the GABAA receptor subtypes. J.Pharmacol.Exp.Ther. 275 761 PMID: 7473164
Keywords: U 90042, supplier, GABAA, receptor, ligands, Receptors, U90042, GABAA, Receptors, GABAA, Receptors, Tocris Bioscience
