Biological Activity
Potent, selective D3 antagonist. Ki values are 160, 2281 and > 10000 nM for human cloned D3, D2 and D4 receptors respectively.
Technical Data
| M. Wt | 393.48 |
| Formula | C17H27NO2.C4H4O4 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 234757-41-6 |
| PubChem ID | 11957713 |
| InChI Key | FSIQDESGRQTFNN-BTJKTKAUSA-N |
| Smiles | OC(=O)C=C/C(O)=O.CCCN(CCC)C1CC2=C(C1)C=C(OC)C(OC)=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 9.84 | 25 |
Preparing Stock Solutions
The following data is based on the product molecular weight 393.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.54 mL | 12.71 mL | 25.41 mL |
| 5 mM | 0.51 mL | 2.54 mL | 5.08 mL |
| 10 mM | 0.25 mL | 1.27 mL | 2.54 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.51 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Audinot et al (1998) A comparative in vitro and in vivo pharmacological characterization of the novel dopamine D3 receptor antagonists (+)-S 14297, nafadotride, GR 103,691 and U 99194. J.Pharmacol.Exp.Ther. 287 187 PMID: 9765337
Clifford and Waddington (1998) Heterogeneity of behavioural profile between three putative selective D3 dopamine receptor antagonists using an ethologically based approach. Psychopharmacology 136 284 PMID: 9566814
LaHoste et al (2000) Dopamine D1 receptors synergize with D2, but not D3 or D4, receptors in the striatum without the involvement of action potentials. J.Neurosci. 20 6666 PMID: 10964971
Keywords: U 99194 maleate, supplier, Potent, selective, D3, antagonists, Dopamine, Receptors, dopaminergic, U99194, maleate, PNU99194, PNU, 99194, D3, Receptors, D3, Receptors, Tocris Bioscience
