Biological Activity
Inactive analog of U0126 (Cat. No. 1144). Used as a negative control. Does not inhibit MEK at concentrations up to 100 μM.
Technical Data
| M. Wt | 226.31 |
| Formula | C8H10N4S2 |
| Storage | Store at RT |
| CAS Number | 108923-79-1 |
| PubChem ID | 5842955 |
| InChI Key | LBQNBMSPTURKGS-KQQUZDAGSA-N |
| Smiles | N/C(SC)=C(C(C#N)=C(SC)/N)/C#N |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 22.63 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 226.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.42 mL | 22.09 mL | 44.19 mL |
| 5 mM | 0.88 mL | 4.42 mL | 8.84 mL |
| 10 mM | 0.44 mL | 2.21 mL | 4.42 mL |
| 50 mM | 0.09 mL | 0.44 mL | 0.88 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Favata et al (1998) Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J.Biol.Chem. 273 18623 PMID: 9660836
Fitzgerald (2000) Regulation of voltage-dependent calcium channels in rat sensory neurones involves a Ras-mitogen-activated protein kinase pathway. J.Physiol. 527 433 PMID: 10990531
Sekar et al (2001) Concerted transcriptional activation of the low density lipoprotein receptor gene by insulin and luteinizing hormone in cultured porcine granulosa-luteal cells: possible convergence of protein kinase A, phosphatidylinositol 3-kinase, and mitogen-activated Endocrinology 142 2921 PMID: 11416012
Keywords: U0124, supplier, Mitogen-Activated, Protein, Kinase, kinases, MEK, MEK, MEK, Tocris Bioscience
