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Tocris Bioscience(优势品牌)
主营:主营:分子类,蛋白类,抗体类,生化类试剂
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当前位置: 首页 > 产品中心 > Other_enzymes > Tocris/U0126/1144/25/25 mg
商品详细Tocris/U0126/1144/25/25 mg
Tocris/U0126/1144/25/25 mg
Tocris/U0126/1144/25/25 mg
商品编号: 1144/25
品牌: Tocris Bioscience
市场价: ¥16500.00
美元价: 9900.00
产地: 美国(厂家直采)
公司:
产品分类: 其它酶
公司分类: Other_enzymes
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Description:Potent,selectiveinhibitorofMEK1and2
ChemicalName:1,4-Diamino-2,3-dicyano-1,4-bis[2-aminophenylthio]butADIene
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Potentandselectivenon-competitiveinhibitorofMAPkinasekinase.InhibitsMEK-1andMEK-2(IC50valuesof0.07and0.06μMrespectively)withlittleornoeffectontheactivitiesofPKC,Abl,Raf,MEKK,ERK,JNK,MKK-3,MKK-4/SEK,MKK-6,Cdk2orCdk4.Brainpenetrant.Helpsmaintainhumanpluripotentstemcellsinundifferentiatedstate.AlsoavailableaspartoftheMAPKCascadeInhibitorTocriset™andMAPKInhibitorTocriset™.NegativecontrolU0124(Cat.No.1868)alsoavailable.

CompoundLibraries

U0126isalsoofferedaspartoftheTocriscreenEpigeneticsToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt380.48
FormulaC18H16N6S2
StorageDesiccateat+4°C
CASNumber109511-58-2
PubChemID3006531
InChIKeyDVEXZJFMOKTQEZ-JYFOCSDGSA-N
SmilesNC(SC1=CC=CC=C1N)=C(C#N)/C(C#N)=C(N)SC1=CC=CC=C1N

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO38.05100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight380.48.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.63mL13.14mL26.28mL
5mM0.53mL2.63mL5.26mL
10mM0.26mL1.31mL2.63mL
50mM0.05mL0.26mL0.53mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet