BiologicalActivity
Potentandselectivenon-competitiveinhibitorofMAPkinasekinase.InhibitsMEK-1andMEK-2(IC50valuesof0.07and0.06μMrespectively)withlittleornoeffectontheactivitiesofPKC,Abl,Raf,MEKK,ERK,JNK,MKK-3,MKK-4/SEK,MKK-6,Cdk2orCdk4.Brainpenetrant.Helpsmaintainhumanpluripotentstemcellsinundifferentiatedstate.AlsoavailableaspartoftheMAPKCascadeInhibitorTocriset™andMAPKInhibitorTocriset™.NegativecontrolU0124(Cat.No.1868)alsoavailable.
CompoundLibraries
U0126isalsoofferedaspartoftheTocriscreenEpigeneticsToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 380.48 |
| Formula | C18H16N6S2 |
| Storage | Desiccateat+4°C |
| CASNumber | 109511-58-2 |
| PubChemID | 3006531 |
| InChIKey | DVEXZJFMOKTQEZ-JYFOCSDGSA-N |
| Smiles | NC(SC1=CC=CC=C1N)=C(C#N)/C(C#N)=C(N)SC1=CC=CC=C1N |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 38.05 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight380.48.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.63mL | 13.14mL | 26.28mL |
| 5mM | 0.53mL | 2.63mL | 5.26mL |
| 10mM | 0.26mL | 1.31mL | 2.63mL |
| 50mM | 0.05mL | 0.26mL | 0.53mL |
MolarityCalculator
ReconstitutionCalculator
DilutionCalculator
ProductDatasheets
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